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Contraindicated (one)pentobarbital will reduce the level or influence of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with solid CYP3A4 inducers isn't recommendedSteer clear of; coadministration with CYP3A inducers may well lead to lowered plasma concentrations of elvitegravir and/or perhap